Effect of adrenaline on the distribution of bupivacaine in the rabbit fetus.
نویسندگان
چکیده
Adrenaline may decrease uterine blood flow and influence transplacental distribution of bupivacaine. Sixteen pregnant rabbits received an i.v. infusion of 0.125% bupivacaine either plain (n = 8) or with adrenaline 1.25 microgram ml-1. At 15-min intervals following the start of the infusion, rabbit fetuses were removed serially and bupivacaine concentrations measured in maternal arterial plasma, fetal plasma and brain, amniotic fluid and placenta. The presence of adrenaline was associated with increased bupivacaine concentration in placenta; there was no other significant effect on fetal bupivacaine concentrations or ratios. Fetal:maternal plasma ratios increased (P less than 0.05), while fetal brain:fetal plasma ratios decreased (P less than 0.05) significantly with time.
منابع مشابه
Effect of adrenaline on placental transfer of bupivacaine in the perfused in situ rabbit placenta.
Following general anaesthesia, each of 18 pregnant rabbits received an i.v. infusion, at a declining rate, of 0.125% bupivacaine, either plain solution followed by adrenaline (1.25 micrograms ml-1)-containing solution (n = 10) or vice versa (n = 8). All solutions contained antipyrine as an index of placental exchange. In each rabbit, a single fetal sac was opened, the umbilical vessels were can...
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ورودعنوان ژورنال:
- British journal of anaesthesia
دوره 63 6 شماره
صفحات -
تاریخ انتشار 1989